Although the genetic contribution to bipolar disorder has been unequivocally demonstrated, few specific genetic risk factors have been confirmed. The factors identified explain only a small proportion of the genetic contribution to bipolar disorder. Mark A. Frye, M.D., chair of the Department of Psychiatry and Psychology, discusses the Mayo Clinic Center for Individualized Medicine's Biobank for Bipolar Disorder, a resource for the bipolar research community working to confirm those risk factors and discover additional contributors to bipolar disorder susceptibility and response to treatment.