Mayo Clinic psychiatrist Mark A. Frye, M.D., discusses individualized depression treatment and antidepressant-induced mania. Dr. Frye tells the story of a patient struggling with bipolar disorder who became manic after taking an antidepressant. Cases like this are not frequent, but have potentially disastrous consequences. The Mayo Clinic Depression Center has identified risk factors for switching from depression to mania. With assistance from the Mayo Clinic Center for Individualized Medicine, Depression Center physicians are studying areas of potential genetic variation, such as the serotonin transporter. There are currently a number of Mayo Clinic Depression Center studies and trials underway to examine pharmacogenomics and how physicians might best individualize clinical practices for people with depression.